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02 February 2009, 10:52

Genetic variations associated with treatment response for childhood leukemia

Paediatric acute lymphoblastic leukaemia (ALL) cure rates obtain increased from less than 10 percent in the 1960s to enhanced than 80 percent today, although appreciable unexplained lone variability exists in treatment response, according to background break in the article. June J. Yang, Ph.D., St.


The researchers tested unmarried nucleotide polymorphisms (SNPs; genetic variations) for their partnership with minimal residual disease (MRD) at the objective of initial chemotherapy in two groups (totaling 487 children) treated for newly diagnosed ALL. Patients were enrolled between 1994 and 2006, with the latest follow-up in 2006. The researchers create that there were 102 SNPs associated with MRD in both groups.


All 102 SNPs remained significantly associated with MRD after habituation for race, sex, leukocyte (a type of blood cell) count at diagnosis, age, and ALL subtype. Of the 102 SNPs, 21 were significantly associated with hematologic (blood-related) relapse. Of 102 SNPs, 21 were besides associated with antileukemic narcotic disposition, generally linking MRD eradication with in a superior way drug exposure.


The researchers establish that a eminent proportion (63 of 102 SNPs 61.7 percent ) further were associated with early response, relapse risk, or antileukemic drug disposition.



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