American Chronology of Clinical Nutrition, Vol. 87, No. Objective: The nondiscriminatory of this peruse was to investigate physiologic adaptations to weight loss that may enhearten weight regain. Design: The glance at had a within-subject repeated-measure originate 12 healthy, overweight men, 33-64 y, oppose bulk index (in kg m 2 ) 30-46 and was a clinical intervention question of circulating metabolites and hunger-satiety responses before and after weight loss.

Measures included anthropometry (bioelectrical impedance, entity weight, and waist circumference), concentrations of circulating hormones and metabolites ketone bodies, for free fatty acids (FFAs), insulin, leptin, glucose, and cholecystokinin (CCK), and measures of famine and satiety at baseline, 8 wk after weight loss with a very-low-energy diet, and 1 wk after weight maintenance. Results: Weight loss led to a lessening in postprandial CCK secretion ( P 0.016).

However, when subjects were ketotic (elevated circulating & 946;-hydroxybutyrate concentrations), CCK secretion was sustained at concentrations before weight loss. After weight loss, there were reduced postprandial FFA concentrations ( P 0.0005). The presence of ketosis sustained FFA to concentrations before weight loss ( P 0.60).

Conclusion: Hurried weight loss of 10% of initial thing weight results in a decrease in postprandial CCK and FFA concentrations.

It was remain updated at 09:26 on May 12 2008. Would Lionel Barber, editor of the Financial Times, help the views of The Gray Cardigan, the pseudonymous Press Gazette columnist who caricatures the views of a crusty full of years manager sub?

You can fancy what you analogous approximately me," The Grey Cardigan wrote recently, "but I honestly cannot afford to appoint a senior subeditor who's immediately going to piss off pregnant for a year." Women with "active ovaries", he complains, pitch a tightly-resourced material transaction into chaos. Whether appointed to senior jobs, they should be setting the paper's tone for the later five years.

Instead, they disappear for months and, on returning, demand individual part-time commitments "due to childcare issues". When Barber took over in Nov 2005, the FT, once an overwhelmingly masculine paper, was regarded as an production doyen in creating identical opportunities. The three most senior positions below the editor - deputy editor, managing editor and cognizance editor - were held by women.

Moreover, the broadcast editorship, a exceeding able chore than in most papers as it controls the election of front folio stories, was a job-share. Still before he became editor, Barber had let it be certified to senior figures that he believed a occupation so crucial to the paper's ego and government should not be shared. Momentarily he is the editor, all three of those senior positions are held by men and onliest 17% of associate and assistant editors - the adjoining flush of seniority - are women.

Jon Snow, the host, asked in semi-jocular fashion, "where are all the women?" The Governmental Union of Journalists chapel, which says women on criterion earn 11% less than men and is currently locked in a pament dispute, decisive to "use the desired equality legislation" to residence "massive anomalies in pay". Is Barber, who is 53 and the sonny of a crusty, Yorkshire-born subeditor who was described in his obituary as "forthright in speech", an unreconstructed person chauvinist?

Is the FT nowadays unfriendly to women? Provided so, is it any worse than the rest of Fleet Street? The Guardian, for the record, is completing an internal audit of salaries on the other hand says it has so far constitute no evidence of systematic gender disparity.)

An FT spokeswoman insisted that, if there is a "gender earnings gap" for dudes doing consubstantial jobs, it is entirely due to length of service: women, on average, get eight oldness against men's 11, she said. This doesn't cause still concept being newspapers, unlike, say, the civil service, don't admit recompense scales with annual increments.)

Barber himself reels off a folder of women he has promoted to associate or assistant editorships. They comprise Lucy Kellaway, a star columnist; Roula Khalef, who oversees the Centre East edition; Gillian Tett, who is in charge of financial coverage; Gillian de Bono, editor of the How to Spend It abbreviate of FT Weekend.

Though Chrystia Freeland is no longer deputy editor, she moved to US managing editor, a position that was Barber's stepping stone to the FT editorship and Robert Thomson's to the Times editorship. Merit things most," Barber said. We don't conclude tokens. I corner no distort against part-time working or job-sharing at all.

Nevertheless there are a scarce jobs where you longing brisk decisions and sunshiny lines of authority." Man's adult You all the more jewel expanded female bylines in the FT than you might expect in a racket paper; about a third of the journalists are women and the proportion has risen slightly under Barber. However that, as distinct women pointed out, makes a decrease of senior women all the amassed lamentable. It's an empire built on toiling, low-paid females," said one.

I spoke to assorted journalists nowadays working at the FT as fine as others who own recently left. Though none would be quoted, all agreed Barber is a traditional "man's man" and it shows in the action he runs the paper. It's no longer a culture that rewards muted effectiveness," one insider said.

If you're not somebody who makes a barn door song and dance about how beefy you're doing your job, editorial authority won't bother to cost you. In the past, positive bill was placed on lifetime collegiate, working in teams, sharing stories, exchanging contacts. First off it's all 'I'm the one bringing in the story'. There aren't abounding part-time or job-sharing arrangements now.

So if you are part-time, you don't gaze divers opportunities to switch jobs and boost your fee and being prospects." Another insider (male) cognition it was all summed up by "the bollocks par". This is apparently the paragraph, high rise up in a dope story, which is supposed to elucidate its significance. Message editors testament assert a chronicle 'needs else bollocks'.

You include meetings of eight or 10 men with one or two women and all the blokes are banging on about bollocks." A former FT reporter (also male) said: "Lionel is the category of human race who, if he sees a woman standing around, asks her to fetch him a glass of water." Barber shrugs off allocution of his machismo, saying "each editor has his own style".